On This Date: Tiny Centre College Beats Mighty Harvard (Oct. 29, 1921)
On Oct. 29, 1921, tiny Centre College beat Harvard 6-0 on a Bo McMillin touchdown run, ending a 25-game unbeaten streak and giving the world C6H0.
In 1950, the Associated Press asked sportswriters to name the greatest upset of the first half of the 20th century. They didn’t pick a boxing match or a World Series. They picked a college football game between Harvard and a Kentucky school with a few hundred students.
On Oct. 29, 1921, Centre College beat Harvard 6-0.

David and Goliath
In 1921, Harvard was college football royalty. The Crimson hadn’t lost a game since November 1916, a run of 25 games without a loss, and they had won the Rose Bowl less than 2 years earlier. They had 17 coaches.
Centre College was in Danville, Kentucky, and had somewhere around 300 students. Its coach, Charley Moran, also worked as a National League umpire in the summer. Its stars were a quarterback from Fort Worth named Alvin “Bo” McMillin and 2 linemen everybody called Red, Red Roberts and Red Weaver. Before games they prayed in the locker room, which got them a nickname, the Praying Colonels.


The 2 schools had met once before. In 1920, Centre went to Cambridge and was tied with Harvard 14-14 at halftime before running out of gas and losing 31-14. When Harvard’s Arnold Horween offered McMillin the game ball afterward, he turned it down. Centre, he said, would be back to take one home.



The Game
They came back with 28 players, unbeaten. Harvard was still a 3-to-1 favorite, and about 45,000 people filled Harvard Stadium for a 2:30 kickoff.


The first half was a scoreless grind. Harvard missed 2 field goals.

Less than 2 minutes into the 2nd half, Harvard was flagged 15 yards for tripping, and Centre had a first down near the Harvard 25. On the very next play, McMillin started to his right behind Roberts, who knocked over 3 or 4 Harvard men, then cut back through the hole and swept to his left. The Boston Globe measured the run at 32 yards. Nobody touched him. The extra point missed. It didn’t matter.


Harvard drove to the Centre 3-yard line late in the game and was flagged for offside. Centre intercepted a pass on Harvard’s last drive and ran out the clock.

When it ended, about 10,000 fans poured onto the field. They carried McMillin off on their shoulders. The referee handed him the game ball, and students from MIT, across the river, tore down Harvard’s goalposts.
Harvard coach Bob Fisher called McMillin probably the hardest man in the country to stop. In Louisville, the Courier-Journal’s man in the press box reached for the Bible: “This David from the region of the Blue Grass dragged in the dust the Crimson banner of the proud Goliath of the erudite East.”


C6H0
Back in Danville, someone came up with a formula for what had happened. Harvard, a Centre professor said, had been poisoned by an impossible compound: C6H0.
Students carved “C6 H0” into a wall on campus that day and painted it all over town. Danville had already lost its mind. When the news came over the wire that afternoon, the fire department drove around in the rain with nowhere to go, the factory whistles and church bells went off, and thousands of people paraded up and down the streets. The Courier-Journal’s correspondent spotted “a painted cow, with a demented college boy on its back.”

When the team’s train got back to Danville on Monday, about 10,000 people were waiting, including the governor of Kentucky, Edwin P. Morrow. The college canceled classes. “I’d rather be Bo McMillin at this moment than the governor of Kentucky,” Morrow said.



The players had reportedly bet heavily on themselves. A Louisville Courier-Journal reporter wrote that McMillin rode home carrying more cash than a small bank.
What Came After
Centre finished the regular season 9-0 and beat Arizona 38-0 in a Christmas game in San Diego. On Jan. 2, 1922, it lost 22-14 to Texas A&M in Dallas, in the game that started A&M’s “12th Man” tradition. McMillin got married that morning.

Harvard got its rematch in 1922 and won 24-10. The schools haven’t played since. Harvard plays in the FCS now and Centre in Division III, and every time Centre has proposed an anniversary game, Harvard has said no.
McMillin went into the College Football Hall of Fame in 1951 and spent decades as a coach, at Indiana and in the NFL. At Centre, C6H0 is still on the shirts.


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